Myeloperoxidase-Mediated Dysfunctional High-Density Lipoprotein
نویسندگان
چکیده
منابع مشابه
Myeloperoxidase-mediated dysfunctional high-density lipoprotein.
T he oxidation of lipoproteins plays an important role in atherogenesis. Most studies have focused on the oxidation of low-density lipoprotein, occurring to a significant extent in the arterial intima leading to the formation of the characteristic foam cell of the atherosclerotic plaque. 1 However, the oxidation of the proteins of high-density lipoprotein (HDL) is thought to substantially atten...
متن کاملAntioxidant Effects of Vitamins C and E on the Low-Density Lipoprotein Oxidation Mediated by Myeloperoxidase
Background: Oxidative modification of low-density lipoprotein (LDL) appears to be an early step in the pathogenesis of atherosclerosis. Meanwhile, myeloperoxidase (MPO)-catalyzed reaction is one of the potent pathway for LDL oxidation in vivo. The aim of this study was to evaluate in vitro antioxidant effects of vitamins C and E on LDL oxidation mediated by MPO. Methods: MPO was isolated from f...
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OBJECTIVES This study examined the functionality of high-density lipoprotein (HDL) in individuals with end-stage renal disease on dialysis (ESRD-HD). BACKGROUND The high rate of cardiovascular disease (CVD) in chronic kidney disease is not explained by standard risk factors, especially in patients with ESRD-HD who appear resistant to benefits of statin therapy. HDL is antiatherogenic because ...
متن کاملantioxidant effects of vitamins c and e on the low-density lipoprotein oxidation mediated by myeloperoxidase
background: oxidative modification of low-density lipoprotein (ldl) appears to be an early step in the pathogenesis of atherosclerosis. meanwhile, myeloperoxidase (mpo)-catalyzed reaction is one of the potent pathway for ldl oxidation in vivo. the aim of this study was to evaluate in vitro antioxidant effects of vitamins c and e on ldl oxidation mediated by mpo. methods: mpo was isolated from f...
متن کاملAntioxidant effects of vitamins C and e on the low-density lipoprotein oxidation mediated by myeloperoxidase.
BACKGROUND Oxidative modification of low-density lipoprotein (LDL) appears to be an early step in the pathogenesis of atherosclerosis. Meanwhile, myeloperoxidase (MPO)-catalyzed reaction is one of the potent pathway for LDL oxidation in vivo. The aim of this study was to evaluate in vitro antioxidant effects of vitamins C and E on LDL oxidation mediated by MPO. METHODS MPO was isolated from f...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2014
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.114.303282